Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

In an in vitro nanotoxicity system, cell–nanoparticle (NP) interaction leads to the surface
adsorption, uptake, and changes into nuclei/cell phenotype and chemistry, as an indicator of …

Cristae are high‐curvature structures in the inner mitochondrial membrane (IMM) that are
crucial for ATP production. While cristae‐sha** proteins have been defined, analogous …

Spheroid and organoid cultures are powerful in vitro models for biology, but size and shape
diversity within the culture is largely ignored. To streamline morphometric profiling, we …

Morphogenesis occurs in 3D space over time and is guided by coordinated gene expression
programs. Here we use postembryonic development in Arabidopsis plants to investigate the …

Rapid developments in live-cell three-dimensional (3D) microscopy enable imaging of cell
morphology and signaling with unprecedented detail. However, tools to systematically …

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with
other pathways, and both mechanical and biochemical stimuli. Computational modeling …

Although a great deal is known about the signaling events that promote nuclear
translocation of NF‐κB, how cellular biophysics and the microenvironment might regulate …