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Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
The glymphatic system: a novel component of fundamental neurobiology
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
Identification of a choroid plexus vascular barrier closing during intestinal inflammation
Up to 40% of patients with inflammatory bowel disease present with psychosocial
disturbances. We previously identified a gut vascular barrier that controls the dissemination …
disturbances. We previously identified a gut vascular barrier that controls the dissemination …
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks …
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …
Aging microbiota-gut-brain axis in stroke risk and outcome
The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …
microbes and their host. Many environmental and host-related factors affect the gut …
Neuroinflammation in bipolar depression
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Tissue-resident macrophages: guardians of organ homeostasis
Tissue-resident macrophages (M TR) have recently emerged as a key rheostat capable of
regulating the balance between organ health and disease. In most organs, ontogenetically …
regulating the balance between organ health and disease. In most organs, ontogenetically …
Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation
Background Choroid plexuses (CPs) have been suggested as a key gateway for
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
Inflammatory response in the CNS: friend or foe?
Inflammatory reactions could be both beneficial and detrimental to the brain, depending on
strengths of their activation in various stages of neurodegeneration. Mild activation of …
strengths of their activation in various stages of neurodegeneration. Mild activation of …