Airborne transmission of COVID-19: aerosol dispersion, lung deposition, and virus-receptor interactions
Coronavirus disease 2019 (COVID-19), due to infection by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol …
syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol …
Strategies to enhance drug absorption via nasal and pulmonary routes
New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …
being developed every year, making it vital to find a non-invasive route such as nasal or …
[HTML][HTML] Per-and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells
The toxicity of some per-and polyfluoroalkyl substances (PFASs), such as perfluorooctane
sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing …
sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing …
Challenges and strategies to enhance the systemic absorption of inhaled peptides and proteins
L Qin, Z Cui, Y Wu, H Wang, X Zhang, J Guan… - Pharmaceutical …, 2023 - Springer
Proteins and peptides-based therapeutics are making substantial access to the market due
to their obvious advantages of strong potency, high specificity and desirable safety profile …
to their obvious advantages of strong potency, high specificity and desirable safety profile …
Recent advances in respiratory immunization: A focus on COVID-19 vaccines
X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …
are regarded as powerful weapons in protecting the global population. Although the vast …
[HTML][HTML] An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function
Inhaled substances, such as consumer products, chemicals at the workplace, and
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …
[HTML][HTML] Recent advancements and application of in vitro models for predicting inhalation toxicity in humans
R Bedford, E Perkins, J Clements, M Hollings - Toxicology in Vitro, 2022 - Elsevier
Animals have been indispensable in testing chemicals that can pose a risk to human health,
including those delivered by inhalation. In recent years, the combination of societal debate …
including those delivered by inhalation. In recent years, the combination of societal debate …
Bile acid-induced lung injury: update of reverse translational biology
The presence of bile acids in lung tissue is associated with some clinical features observed
in various medical specialties, but it took time to understand that these are due to a “bile acid …
in various medical specialties, but it took time to understand that these are due to a “bile acid …
[HTML][HTML] Risk assessment of consumer spray products using in vitro lung surfactant function inhibition, exposure modelling and chemical analysis
Consumer spray products release aerosols that can potentially be inhaled and reach the
deep parts of the lungs. A thin layer of liquid, containing a mixture of proteins and lipids …
deep parts of the lungs. A thin layer of liquid, containing a mixture of proteins and lipids …
Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption
PSA Chakravarthy, P Popli, RR Challa… - Journal of Nanoparticle …, 2024 - Springer
In the pursuit of develo** new active ingredients for drug development, bile salts have
emerged as promising substances that can enhance absorption. Their unique properties …
emerged as promising substances that can enhance absorption. Their unique properties …