Therapeutic targeting of tumour myeloid cells
ST Barry, DI Gabrilovich, OJ Sansom… - Nature Reviews …, 2023 - nature.com
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy
The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
Deterministic reprogramming of neutrophils within tumors
MSF Ng, I Kwok, L Tan, C Shi, D Cerezo-Wallis, Y Tan… - Science, 2024 - science.org
Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …
are associated with poor clinical outcomes. Despite recent advances characterizing the …
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
D Hirschhorn, S Budhu, L Kraehenbuehl, M Gigoux… - Cell, 2023 - cell.com
Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because
tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple …
tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple …
Myeloid-derived suppressor cells in cancer and cancer therapy
SA Lasser, FG Ozbay Kurt, I Arkhypov, J Utikal… - Nature Reviews …, 2024 - nature.com
Anticancer agents continue to dominate the list of newly approved drugs, approximately half
of which are immunotherapies. This trend illustrates the considerable promise of cancer …
of which are immunotherapies. This trend illustrates the considerable promise of cancer …
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis
AJ Kwok, A Allcock, RC Ferreira, E Cano-Gamez… - Nature …, 2023 - nature.com
Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …
processes following infection that leads to life-threatening organ dysfunction. Here we …
Functional states of myeloid cells in cancer
L van Vlerken-Ysla, YY Tyurina, VE Kagan… - Cancer cell, 2023 - cell.com
Myeloid cells, comprised of macrophages, dendritic cells, monocytes, and granulocytes,
represent a major component of the tumor microenvironment (TME) and are critically …
represent a major component of the tumor microenvironment (TME) and are critically …
Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …
component of innate immune defense. Understanding the behavior of neutrophils as they …
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
Summary RNA N 6-methyladenosine (m 6 A) modification is implicated in cancer
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
progression. However, the impact of m 6 A on the antitumor effects of radiotherapy and the …
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
myeloid cells with immunosuppressive effects, which undergo massive expansion during …