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Dendritic cells in cancer immunology
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …
tumor immunology research because ICT was discovered through basic studies of immune …
Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …
Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants
The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …
autoimmunity through aggregation of findings from genome-wide association studies …
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …
Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …
Integration of genetic and immunological insights into a model of celiac disease pathogenesis
Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically
susceptible individuals by exposure to cereal gluten proteins. This review integrates insights …
susceptible individuals by exposure to cereal gluten proteins. This review integrates insights …
Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome
Objective Glycans attached to the Fc portion of IgG are important modulators of IgG effector
functions. Interindividual differences in IgG glycome composition are large and they …
functions. Interindividual differences in IgG glycome composition are large and they …
Immunogenetics of systemic lupus erythematosus: a comprehensive review
Our understanding of the genetic basis of systemic lupus erythematosus has progressed
rapidly in recent years. While many genetic polymorphisms have been associated with …
rapidly in recent years. While many genetic polymorphisms have been associated with …
Pharmacological modulation of nucleic acid sensors—therapeutic potential and persisting obstacles
Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …
signalling, play a critical role in the preservation of cellular and organismal homeostasis …