Despite the recent advances in the prediction of protein structures by deep neutral networks,
the elucidation of protein-folding mechanisms remains challenging. A promising theory for …

Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …

Anaplastic lymphoma kinase (ALK) is considered as a validated molecular target in multiple
malignancies, such as non-small cell lung cancer (NSCLC). However, the effectiveness of …

A comprehensive understanding of protein folding includes the knowledge of the formation
of individual secondary structures, tertiary structure, and the effects of non-native contacts on …

Experiments have compared the folding of proteins with different amino acid sequences but
the same basic structure, or fold. Results indicate that folding is robust to sequence …

Membrane transporters mediate cellular uptake of nutrients, signaling molecules and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …

Abstract Guanine nucleotide-binding (G?) proteins have been intensely studied over the
years due to their role as signal transduction proteins. Proper function depends on three …