[HTML][HTML] Identification of required host factors for SARS-CoV-2 infection in human cells
To better understand host-virus genetic dependencies and find potential therapeutic targets
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …
Coronavirus infection and cholesterol metabolism
J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-
depth understanding of molecular functions of viral proteins and their interactions with the …
depth understanding of molecular functions of viral proteins and their interactions with the …
Conflicts over calcium and the treatment of COVID-19
Several recent studies have provided evidence that use of calcium channel blockers
(CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus …
(CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus …
Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV
Since the beginning of the COVID-19 pandemic, large in silico screening studies and
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
Weighted gene co-expression network analysis combined with machine learning validation to identify key modules and hub genes associated with SARS-CoV-2 …
The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives.
Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless …
Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless …
Metabolic reprogramming in COVID-19
T Shen, T Wang - International journal of molecular sciences, 2021 - mdpi.com
Plenty of research has revealed virus induced alternations in metabolic pathways, which is
known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered …
known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered …
Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach
The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other
coronaviruses and has higher rates of mortality than influenza. Identification of effective …
coronaviruses and has higher rates of mortality than influenza. Identification of effective …
Host-virus chimeric events in SARS-CoV-2-infected cells are infrequent and artifactual
The pathogenic mechanisms underlying severe SARS-CoV-2 (severe acute respiratory
syndrome coronavirus 2) infection remain largely unelucidated. High-throughput …
syndrome coronavirus 2) infection remain largely unelucidated. High-throughput …
[HTML][HTML] Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis
Abstract Calcium (Ca 2+) homeostasis is crucial for maintaining physiological processes in
the body, and disruptions in Ca 2+ signaling can lead to various pathological conditions …
the body, and disruptions in Ca 2+ signaling can lead to various pathological conditions …