Research on the discovery and characterization of small, regulatory RNAs in bacteria has
exploded in recent years. These sRNAs act by base pairing with target mRNAs with which …

Over the past two decades, small noncoding RNAs (sRNAs) that regulate mRNAs by short
base pairing have gone from a curiosity to a major class of post-transcriptional regulators in …

Gram-negative and Gram-positive bacteria have evolved elaborate machinery to
biosynthesize and respond to diverse small-molecule signals. As bacteria grow, these …

Staphylococcus aureus is a major pathogen that colonizes about 20% of the human
population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide …

RNA is involved in the regulation of multiple cellular processes, often by forming sequence-
specific base pairs with cellular RNA or DNA targets that must be identified among the large …

The ubiquitous RNA-binding protein, Hfq, has been shown to be required for the fitness and
virulence of an increasing number of bacterial pathogens. Mutants lacking Hfq are often …

Abstract Background Structured noncoding RNAs perform many functions that are essential
for protein synthesis, RNA processing, and gene regulation. Structured RNAs can be …

Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-
sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding …

Persistent and relapsing infections, despite apparently adequate antibiotic therapy, occur
frequently with many pathogens, but it is an especially prominent problem with …

Bacteria constitute a large and diverse class of infectious agents, causing devastating
diseases in humans, animals, and plants. Our understanding of gene expression control …