Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

R Miao, C Jiang, WY Chang, H Zhang, J An, F Ho… - Immunity, 2023 - cell.com
Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Reactive oxygen species: drivers of physiological and pathological processes

J Checa, JM Aran - Journal of Inflammation research, 2020 - Taylor & Francis
Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y **e, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Mechanisms of biological effects of ionic liquids: from single cells to multicellular organisms

KS Egorova, AV Kibardin, AV Posvyatenko… - Chemical …, 2024 - ACS Publications
The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …

Piezocatalytic 2D WS2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism …

Q Truong Hoang, KA Huynh… - Advanced …, 2023 - Wiley Online Library
Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by
piezoelectric polarization under an external mechanical force have emerged as an effective …

Mitochondrial regulation of ferroptosis

B Gan - Journal of Cell Biology, 2021 - rupress.org
Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid
peroxidation. Mitochondria are double-membrane organelles that have essential roles in …

Mitophagy: an emerging role in aging and age-associated diseases

G Chen, G Kroemer, O Kepp - Frontiers in cell and developmental …, 2020 - frontiersin.org
Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by
irregular mitochondrial morphology, insufficient ATP production, accumulation of …

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

RQ Yao, C Ren, ZF **a, YM Yao - Autophagy, 2021 - Taylor & Francis
The structural integrity and functional stability of organelles are prerequisites for the viability
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …