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The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Molecular mechanisms of immunotherapy resistance in triple-negative breast cancer
Y Zheng, S Li, H Tang, X Meng, Q Zheng - Frontiers in Immunology, 2023 - frontiersin.org
The emergence of immunotherapy has profoundly changed the treatment model for triple-
negative breast cancer (TNBC). But the heterogeneity of this disease resulted in significant …
negative breast cancer (TNBC). But the heterogeneity of this disease resulted in significant …
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy
H Yu, J Liu, X Bu, Z Ma, Y Yao, J Li, T Zhang… - Cell Chemical …, 2024 - cell.com
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells,
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
OPG Wheeler, L Unterholzner - Essays in biochemistry, 2023 - portlandpress.com
The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …
Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation
H Tong, Z Jiang, L Song, K Tan, X Yin, C He, J Huang… - Cell Metabolism, 2024 - cell.com
The effect of the serine/glycine-free diet (− SG diet) on colorectal cancer (CRC) remains
unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC …
unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC …
Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis
M Hilwi, K Shulman, I Naroditsky, S Feld… - Cell Death & …, 2024 - nature.com
Unlike the intense research effort devoted to exploring the significance of heparanase in
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …
cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we …
Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins
D Ma, A ** an intracellular delivery system is of key importance in the expansion of protein-
based therapeutics acting on cytosolic or nuclear targets. Recently, extracellular vesicles …
based therapeutics acting on cytosolic or nuclear targets. Recently, extracellular vesicles …
Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma
L Cerchietti - Blood, 2024 - ashpublications.org
Cells in the tumor microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL) show
enormous diversity and plasticity, with functions that can range from tumor inhibitory to tumor …
enormous diversity and plasticity, with functions that can range from tumor inhibitory to tumor …
[HTML][HTML] Epigenetic deregulation in breast cancer microenvironment: Implications for tumor progression and therapeutic strategies
L Trnkova, V Buocikova, M Mego, A Cumova… - Biomedicine & …, 2024 - Elsevier
Breast cancer comprises a substantial proportion of cancer diagnoses in women and is a
primary cause of cancer-related mortality. While hormone-responsive cases generally have …
primary cause of cancer-related mortality. While hormone-responsive cases generally have …
Belling the “cat”: Wnt/β-catenin signaling and its significance in future cancer therapies
The WNT/β-catenin is among one of the most extensively studied cellular signaling
pathways involved in the initiation and progression of several deadly cancers. It is now …
pathways involved in the initiation and progression of several deadly cancers. It is now …