Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Macrophages perform diverse functions within tissues during immune responses to
pathogens and injury, but molecular mechanisms by which physical properties of the tissue …

Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …

Macrophages are innate immune cells that adhere to the extracellular matrix within tissues.
However, how matrix properties regulate their function remains poorly understood. Here, we …

Macrophages are key players of the innate immune system that can roughly be divided into
the pro-inflammatory M1 type and the anti-inflammatory, pro-healing M2 type. While a …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

An appropriate immune microenvironment, governed by macrophages, is essential for rapid
tissue regeneration after biomaterial implantation. The macrophage phenotypes, M1 …