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Fluorescence-guided surgical techniques in adult diffuse low-grade gliomas: state-of-the-art and emerging techniques: a systematic review
Simple Summary In the era of targeted therapies, achieving a maximal safe resection still
remains a critical prognosis factor in diffuse low-grade gliomas and represents the goal to …
remains a critical prognosis factor in diffuse low-grade gliomas and represents the goal to …
Towards machine learning-based quantitative hyperspectral image guidance for brain tumor resection
Background Complete resection of malignant gliomas is hampered by the difficulty in
distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists …
distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists …
Spectral complexity of 5-ALA induced PpIX fluorescence in guided surgery: a clinical study towards the discrimination of healthy tissue and margin boundaries in high …
Gliomas are diffuse and hard to cure brain tumors. A major reason for their aggressive
behavior is their property to infiltrate the brain. The gross appearance of the infiltrative …
behavior is their property to infiltrate the brain. The gross appearance of the infiltrative …
Characterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery
Aminolevulinic acid (5-ALA)-mediated fluorescence does not effectively depict low grade
gliomas (LGG) or the infiltrative tumor portion of high-grade gliomas (HGG). While …
gliomas (LGG) or the infiltrative tumor portion of high-grade gliomas (HGG). While …
Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements
The visualization of protoporphyrin IX (PPIX) fluorescence with the help of surgical
microscopes during 5-aminolevulinic acid-mediated fluorescence-guided resection (FGR) of …
microscopes during 5-aminolevulinic acid-mediated fluorescence-guided resection (FGR) of …
5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review
The review begins with an overview of the fundamental principles/physics underlying light,
fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5 …
fluorescence, and other light-matter interactions in biological tissues. It then focuses on 5 …
5-Aminolevulinic acid-induced porphyrin contents in various brain tumors: implications regarding imaging device design and their validation
BACKGROUND Fluorescence-guided resections using 5-aminolevulinic acid (5-ALA)-
induced tumor porphyrins have been established as an adjunct for malignant glioma surgery …
induced tumor porphyrins have been established as an adjunct for malignant glioma surgery …
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy
Gliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX
fluorescence measurements are a clinical standard, but expert-based classification models …
fluorescence measurements are a clinical standard, but expert-based classification models …
Unraveling the blue shift in porphyrin fluorescence in glioma: The 620 nm peak and its potential significance in tumor biology
In glioma surgery, the low-density infiltration zone of tumors is difficult to detect by any
means. While, for instance, 5-aminolevulinic acid (5-ALA)-induced fluorescence is a well …
means. While, for instance, 5-aminolevulinic acid (5-ALA)-induced fluorescence is a well …
An explicit estimated baseline model for robust estimation of fluorophores using multiple-wavelength excitation fluorescence spectroscopy
Spectroscopy is a popular technique for identifying and quantifying fluorophores in
fluorescent materials. However, quantifying the fluorophore of interest can be challenging …
fluorescent materials. However, quantifying the fluorophore of interest can be challenging …