Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer's disease
To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …
Cardiovascular comorbidities, inflammation, and cerebral small vessel disease
LE Evans, JL Taylor, CJ Smith… - Cardiovascular …, 2021 - academic.oup.com
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …
impairment and affects all levels of the brain's vasculature. Features include diverse …
Recent insights into channelopathies
The membrane of cells and intracellular organelles is 2 composed of two layers of lipids,
preventing the free “in 3 and out” movement of water and solutes that are necessary 4 for …
preventing the free “in 3 and out” movement of water and solutes that are necessary 4 for …
Endothelial ion channels and cell-cell communication in the microcirculation
WF Jackson - Frontiers in Physiology, 2022 - frontiersin.org
Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …
From neurodevelopmental to neurodegenerative disorders: the vascular continuum
J Ouellette, B Lacoste - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …
development and function, as well as healthy aging. The inability of the brain to store energy …
Uncoupling of Ca2+ sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia
The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular
dementia is increasingly viewed as a therapeutic target for disease-modifying therapy …
dementia is increasingly viewed as a therapeutic target for disease-modifying therapy …
Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease
Dementia resulting from small vessel diseases (SVDs) of the brain is an emerging epidemic
for which there is no treatment. Hypertension is the major risk factor for SVDs, but how …
for which there is no treatment. Hypertension is the major risk factor for SVDs, but how …
Oxygen flux from capillary to mitochondria: integration of contemporary discoveries
Abstract Resting humans transport~ 100 quintillion (1018) oxygen (O2) molecules every
second to tissues for consumption. The final, short distance (< 50 µm) from capillary to the …
second to tissues for consumption. The final, short distance (< 50 µm) from capillary to the …
Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch
Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
glia, little is known of the contributions of these cells to the control of brain hemodynamics …
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?
From the first described AD case in 1901 to the current year 2022, understanding the
pathogenesis of Alzheimer's disease (AD) and dementia has undergone a long and tortuous …
pathogenesis of Alzheimer's disease (AD) and dementia has undergone a long and tortuous …