The blood–brain barrier in systemic infection and inflammation

I Galea - Cellular & molecular immunology, 2021 - nature.com
The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …

The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions

S Vatansever, A Schlessinger, D Wacker… - Medicinal research …, 2021 - Wiley Online Library
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, develo** drugs for central nervous system (CNS) disorders remains the most …

[HTML][HTML] Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes

RS Pulido, RN Munji, TC Chan, CR Quirk, GA Weiner… - Neuron, 2020 - cell.com
The blood vessels in the central nervous system (CNS) have a series of unique properties,
termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into …

Bridging barriers: a comparative look at the blood–brain barrier across organisms

NM O'Brown, SJ Pfau, C Gu - Genes & development, 2018 - genesdev.cshlp.org
The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases

T Chen, Y Dai, C Hu, Z Lin, S Wang, J Yang… - Fluids and Barriers of …, 2024 - Springer
Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …

Regulation of the blood–brain barrier by circadian rhythms and sleep

VA Cuddapah, SL Zhang, A Sehgal - Trends in neurosciences, 2019 - cell.com
The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …

A circadian clock in the blood-brain barrier regulates xenobiotic efflux

SL Zhang, Z Yue, DM Arnold, G Artiushin, A Sehgal - Cell, 2018 - cell.com
Endogenous circadian rhythms are thought to modulate responses to external factors, but
mechanisms that confer time-of-day differences in organismal responses to environmental …

Drosophila glia: Few cell types and many conserved functions

K Yildirim, J Petri, R Kottmeier, C Klämbt - Glia, 2019 - Wiley Online Library
Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

Hormonal gatekee** via the blood-brain barrier governs caste-specific behavior in ants

L Ju, KM Glastad, L Sheng, J Gospocic, CJ Kingwell… - Cell, 2023 - cell.com
Here, we reveal an unanticipated role of the blood-brain barrier (BBB) in regulating complex
social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone …