The blood–brain barrier in systemic infection and inflammation
I Galea - Cellular & molecular immunology, 2021 - nature.com
The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …
brain. Its primary function is to protect central neurons while signaling the presence of …
The blood–brain barrier in health and disease: Important unanswered questions
CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …
properties that tightly control the movement of ions, molecules, and cells between the blood …
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, develo** drugs for central nervous system (CNS) disorders remains the most …
However, develo** drugs for central nervous system (CNS) disorders remains the most …
[HTML][HTML] Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes
RS Pulido, RN Munji, TC Chan, CR Quirk, GA Weiner… - Neuron, 2020 - cell.com
The blood vessels in the central nervous system (CNS) have a series of unique properties,
termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into …
termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into …
Bridging barriers: a comparative look at the blood–brain barrier across organisms
The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …
brain and is essential for regulating the neural microenvironment. Here, we describe how …
Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases
T Chen, Y Dai, C Hu, Z Lin, S Wang, J Yang… - Fluids and Barriers of …, 2024 - Springer
Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …
Regulation of the blood–brain barrier by circadian rhythms and sleep
The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …
separation between circulating blood and the central nervous system (CNS). By controlling …
A circadian clock in the blood-brain barrier regulates xenobiotic efflux
Endogenous circadian rhythms are thought to modulate responses to external factors, but
mechanisms that confer time-of-day differences in organismal responses to environmental …
mechanisms that confer time-of-day differences in organismal responses to environmental …
Drosophila glia: Few cell types and many conserved functions
K Yildirim, J Petri, R Kottmeier, C Klämbt - Glia, 2019 - Wiley Online Library
Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …
operating nervous system. Work in many labs over the last decades has demonstrated that …
Hormonal gatekee** via the blood-brain barrier governs caste-specific behavior in ants
Here, we reveal an unanticipated role of the blood-brain barrier (BBB) in regulating complex
social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone …
social behavior in ants. Using scRNA-seq, we find localization in the BBB of a key hormone …