The emergence of immune checkpoint blockade therapies over the last decade has
transformed cancer treatment in a wide range of tumor types. Unprecedented and durable …

This review deals with emerging evidence of an association between systemic or local
hypoxia and inflammation in a variety of diseases. The evidence points to new ways of …

The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

The vertebrate immune system is poised in a state of equilibrium that permits accurate and
rapid protective responses against pathogens but curtails potential for causing harm to the …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …

The A2A adenosine receptor (A2AR) has been shown to be a critical and nonredundant
negative regulator of immune cells in protecting normal tissues from inflammatory damage …