Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …