In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of
the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck …

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of
childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in∼ …

One of the two chromosomal breakage events in recurring translocations in B cell
neoplasms is often due to the recombination-activating gene complex (RAG complex) …

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but
also affects a significant proportion of adults in developed countries. The majority of infant …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Abstract The t (1; 19) translocation, encoding the oncogenic fusion protein E2A (TCF3)-
PBX1, is involved in acute lymphoblastic leukemia (ALL) and associated with a pre–B-cell …

Pre-B-cell leukemia transcription factor (PBX) proteins have important roles in the
development of numerous organs. To date, four members of the PBX family have been …

B-cell precursor acute lymphoblastic leukemias (B-ALL) are characterized by the activation
of signaling pathways, which are involved in survival and proliferation of leukemia cells …

Acute lymphoblastic leukemia (ALL) arises from the uncontrolled proliferation of B-cell
precursors (BCP-ALL) or T cells (T-ALL). Current treatment protocols obtain high cure rates …

t (1; 19)(q23; p13) is one of the most common translocation genes in childhood acute
lymphoblastic leukemia (ALL) and is also present in acute myeloid leukemia (AML) and …