Much more than a leak: structure and function of K2P-channels
V Renigunta, G Schlichthörl, J Daut - Pflügers Archiv-European Journal of …, 2015 - Springer
Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …
Two-pore domain potassium channels as drug targets: anesthesia and beyond
A Mathie, EL Veale, KP Cunningham… - Annual review of …, 2021 - annualreviews.org
Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …
Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of …
NSAT Non-sustained atrial tachycardia NSVT Non-sustained ventricular tachycardia PD
Pharmacodynamic P-GP P-glucoprotein PK Pharmacokinetic PM Pacemaker PVT …
Pharmacodynamic P-GP P-glucoprotein PK Pharmacokinetic PM Pacemaker PVT …
Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence
S Rinné, F Schick, K Vowinkel, S Schütte… - Nature …, 2024 - nature.com
Abstract TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain
potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P …
potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P …
A lower X-gate in TASK channels traps inhibitors within the vestibule
TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain
potassium (K2P) channel family—are found in neurons, cardiomyocytes,–and vascular …
potassium (K2P) channel family—are found in neurons, cardiomyocytes,–and vascular …
[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …
Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …
resting membrane potential and modulate action potential repolarization. Members of the …
Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy
F Wiedmann, C Beyersdorf, XB Zhou… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims TASK-1 (K2P3. 1) two-pore-domain potassium channels are atrial-specific
and significantly up-regulated in atrial fibrillation (AF) patients, contributing to AF-related …
and significantly up-regulated in atrial fibrillation (AF) patients, contributing to AF-related …
Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart
A Saint‐Martin Willer, J Santos‐Gomes… - The Journal of …, 2023 - Wiley Online Library
Potassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of
the two‐pore domain potassium channel family, constitutively active at resting membrane …
the two‐pore domain potassium channel family, constitutively active at resting membrane …
Targets for obstructive sleep apnea pharmacotherapy: principles, approaches, and emerging strategies
RL Horner - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Obstructive sleep apnea (OSA) is a common and serious breathing disorder.
Several pathophysiological factors predispose individuals to OSA. These factors are …
Several pathophysiological factors predispose individuals to OSA. These factors are …