Much more than a leak: structure and function of K2P-channels

V Renigunta, G Schlichthörl, J Daut - Pflügers Archiv-European Journal of …, 2015 - Springer
Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …

Two-pore domain potassium channels as drug targets: anesthesia and beyond

A Mathie, EL Veale, KP Cunningham… - Annual review of …, 2021 - annualreviews.org
Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …

Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of …

GA Dan, A Martinez-Rubio, S Agewall, G Boriani… - Ep …, 2018 - academic.oup.com
NSAT Non-sustained atrial tachycardia NSVT Non-sustained ventricular tachycardia PD
Pharmacodynamic P-GP P-glucoprotein PK Pharmacokinetic PM Pacemaker PVT …

Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence

S Rinné, F Schick, K Vowinkel, S Schütte… - Nature …, 2024 - nature.com
Abstract TASK-5 (KCNK15) belongs to the acid-sensitive subfamily of two-pore domain
potassium (K2P) channels, which includes TASK-1 and TASK-3. TASK-5 stands out as K2P …

A lower X-gate in TASK channels traps inhibitors within the vestibule

KEJ Rödström, AK Kiper, W Zhang, S Rinne, ACW Pike… - Nature, 2020 - nature.com
TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain
potassium (K2P) channel family—are found in neurons, cardiomyocytes,–and vascular …

[HTML][HTML] Structural insights into the mechanisms and pharmacology of K2P potassium channels

AM Natale, PE Deal, DL Minor Jr - Journal of molecular biology, 2021 - Elsevier
Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes

F Wiedmann, N Frey, C Schmidt - Cells, 2021 - mdpi.com
Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …

Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy

F Wiedmann, C Beyersdorf, XB Zhou… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims TASK-1 (K2P3. 1) two-pore-domain potassium channels are atrial-specific
and significantly up-regulated in atrial fibrillation (AF) patients, contributing to AF-related …

Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart

A Saint‐Martin Willer, J Santos‐Gomes… - The Journal of …, 2023 - Wiley Online Library
Potassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of
the two‐pore domain potassium channel family, constitutively active at resting membrane …

Targets for obstructive sleep apnea pharmacotherapy: principles, approaches, and emerging strategies

RL Horner - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Obstructive sleep apnea (OSA) is a common and serious breathing disorder.
Several pathophysiological factors predispose individuals to OSA. These factors are …