The trRosetta server for fast and accurate protein structure prediction
The trRosetta (transform-restrained Rosetta) server is a web-based platform for fast and
accurate protein structure prediction, powered by deep learning and Rosetta. With the input …
accurate protein structure prediction, powered by deep learning and Rosetta. With the input …
Cross-linking mass spectrometry for investigating protein conformations and protein–protein interactions─ a method for all seasons
Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …
Landscape of mSWI/SNF chromatin remodeling complex perturbations in neurodevelopmental disorders
DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
Pharmacological targeting of the cancer epigenome
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …
disease initiation, maintenance and therapy resistance. As a result, there have been …
[HTML][HTML] A disordered region controls cBAF activity via condensation and partner recruitment
Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
protein content. The prevailing dogma is that IDRs engage in non-specific interactions …
Acute BAF perturbation causes immediate changes in chromatin accessibility
Abstract Cancer-associated, loss-of-function mutations in genes encoding subunits of the
BRG1/BRM-associated factor (BAF) chromatin-remodeling complexes,,,,,,–often cause …
BRG1/BRM-associated factor (BAF) chromatin-remodeling complexes,,,,,,–often cause …
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome
J Yuan, K Chen, W Zhang, Z Chen - Nature, 2022 - nature.com
DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …
SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy
The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation,
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine …
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate–dependent chromatin
remodelers modulate genomic architecture and gene expression and are frequently mutated …
remodelers modulate genomic architecture and gene expression and are frequently mutated …
Chromatin remodellers as therapeutic targets
HA Malone, CWM Roberts - Nature Reviews Drug Discovery, 2024 - nature.com
Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …