Advances in diagnosis and management of cancer of the esophagus

N Deboever, CM Jones, K Yamashita, JA Ajani… - Bmj, 2024 - bmj.com
Esophageal cancer is the seventh most common malignancy worldwide, with over 470 000
new cases diagnosed each year. Two distinct histological subtypes predominate, and …

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinoma

S Marcazzan, MJ Braz Carvalho, NT Nguyen… - Journal of Experimental …, 2024 - Springer
Background Esophageal cancer is one of the 10 most common cancers worldwide and its
incidence is dramatically increasing. Despite some improvements, the current surveillance …

Performance assessment and quality control of fluorescence molecular endoscopy with a multi-parametric rigid standard

A Tenditnaya, RY Gabriëls… - … on Medical Imaging, 2024 - ieeexplore.ieee.org
Fluorescence molecular endoscopy (FME) is emerging as a “red-flag” technique with
potential to deliver earlier, faster, and more personalized detection of disease in the …

Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease

RY Gabriëls, AM van der Waaij, MD Linssen, M Dobosz… - Gut, 2024 - gut.bmj.com
Objective Improving patient selection and development of biological therapies such as
vedolizumab in IBD requires a thorough understanding of the mechanism of action and …

Improved ex vivo fluorescence imaging of human head and neck cancer using the peptide tracer TPP-IRDye800 targeting membrane-bound Hsp70 on tumor cells

KLK Holzmann, JL Wolf, S Stangl, P Lennartz… - British Journal of …, 2024 - nature.com
Background The primary goal of surgery in HNSCC is the complete resection of tumor cells
with maximum preservation of normal tissue. The membrane Hsp70-targeting fluorescence …

Detection of tumour-targeted IRDye800CW tracer with commercially available laparoscopic surgical systems

DJ Sikkenk, AJ Sterkenburg, I Schmidt, D Gorpas… - Diagnostics, 2023 - mdpi.com
(1) Introduction: Near-infrared fluorescence (NIRF) combined with tumour-targeted tracers,
such as bevacizumab-800CW, could aid surgical decision-making. This study explored the …

Targeting c-MET for Endoscopic Detection of Dysplastic Lesions within Barrett's Esophagus Using EMI-137 Fluorescence Imaging

YJ Huang, J Rieder, KV Tan, A Tenditnaya… - Clinical Cancer …, 2025 - aacrjournals.org
Purpose: Esophageal cancer carries a poor prognosis with a 5-year overall survival of less
than 20%. Barrett's esophagus increases the risk of esophageal adenocarcinoma. The aim …

Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation

RD Houvast, M van Duijvenvoorde, K Thijse… - Molecular Diagnosis & …, 2024 - Springer
Purpose Tumor-targeted positron emission tomography (PET) and fluorescence-guided
surgery (FGS) could address current challenges in pre-and intraoperative imaging of gastric …

Effects of Neoadjuvant Therapy on Tumour Target Expression of Oesophageal Cancer Tissue for NIR Fluorescence Imaging

HA Galema, LKA Neijenhuis, LJ Lauwerends… - Molecular Imaging and …, 2024 - Springer
Purpose Oesophaegal cancer patients with a clinical complete response (CR) after
neoadjuvant chemoradiotherapy (nCRT) are candidates for an active surveillance strategy …

Selecting Targets for Molecular Imaging of Gastric Cancer

RD Houvast, M van Duijvenvoorde, K Thijse… - 2024 - repository.tudelft.nl
Purpose Tumor-targeted positron emission tomography (PET) and fluorescence-guided
surgery (FGS) could address current challenges in pre-and intraoperative imaging of gastric …