Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

Morphine is a widely used opioid for treatment of moderate to severe pain, but large
interindividual variability in patient response and no clear guidance on how to optimise …

Visceral pain can be difficult to treat with classical μ-opioid agonists and it has been
suggested to use opioids with distinct pharmacological profiles. In animal experiments …

Treatment of pain is one of the major challenges in clinical medicine. However, it is often
difficult to evaluate the effect of a treatment, as the many symptoms of the underlying …

Pain mechanisms in patients with chronic pancreatitis are incompletely understood and
probably multifactorial. Recently, evidence from experimental human pain research has …

Human experimental pain models are essential in understanding the pain mechanisms and
appear to be ideally suited to test analgesic compounds. The challenge that confronts both …

Background Studies using somatic pain models have shown the hypoalgesic effects of slow,
deep breathing. We evaluated the effect of slow, deep breathing on visceral pain and …