[HTML][HTML] The role of the nitric oxide pathway in brain injury and its treatment—from bench to bedside

PS Garry, M Ezra, MJ Rowland, J Westbrook… - Experimental …, 2015 - Elsevier
Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

[HTML][HTML] What is the key mediator of the neurovascular coupling response?

PS Hosford, AV Gourine - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …

Exact discovery of time series motifs

A Mueen, E Keogh, Q Zhu, S Cash, B Westover - Proceedings of the 2009 …, 2009 - SIAM
Time series motifs are pairs of individual time series, or subsequences of a longer time
series, which are very similar to each other. As with their discrete analogues in …

Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex

K Schulz, E Sydekum, R Krueppel, CJ Engelbrecht… - Nature …, 2012 - nature.com
Functional magnetic resonance imaging (fMRI) based on blood oxygen level–dependent
(BOLD) contrast is widely used for probing brain activity, but its relationship to underlying …

The neurovascular unit in brain function and disease

C Lecrux, E Hamel - Acta physiologica, 2011 - Wiley Online Library
Neurovascular coupling, or functional hyperaemia, refers to complex mechanisms of
communication between neurons, astrocytes and cerebral vessels which form the …

mTOR attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling Alzheimer's disease

CE Van Skike, SA Hussong, SF Hernandez… - Journal of …, 2021 - Soc Neuroscience
Vascular dysfunction is a universal feature of aging and decreased cerebral blood flow has
been identified as an early event in the pathogenesis of Alzheimer9s disease (AD) …

nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

CT Echagarruga, KW Gheres, JN Norwood, PJ Drew - Elife, 2020 - elifesciences.org
Cortical neural activity is coupled to local arterial diameter and blood flow. However, which
neurons control the dynamics of cerebral arteries is not well understood. We dissected the …

Functional reactivity of cerebral capillaries

B Stefanovic, E Hutchinson… - Journal of Cerebral …, 2008 - journals.sagepub.com
The spatiotemporal evolution of cerebral microcirculatory adjustments to functional brain
stimulation is the fundamental determinant of the functional specificity of hemodynamically …

[BOOK][B] Simultaneous EEG and fMRI: recording, analysis, and application

M Ullsperger, S Debener - 2010 - books.google.com
One of the major challenges in science is to study and understand the human brain.
Numerous methods examining different aspects of brain functions have been developed …

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration

CF Lourenço, A Ledo, RM Barbosa… - Free Radical Biology and …, 2017 - Elsevier
The strict energetic demands of the brain require that nutrient supply and usage be fine-
tuned in accordance with the specific temporal and spatial patterns of ever-changing levels …