Claudin switching: physiological plasticity of the tight junction

CT Capaldo, A Nusrat - Seminars in cell & developmental biology, 2015 - Elsevier
Abstract Tight Junctions (TJs) are multi-molecular complexes in epithelial tissues that
regulate paracellular permeability. Within the TJ complex, claudins proteins span the …

Claudins: vital partners in transcellular and paracellular transport coupling

D Günzel - Pflügers Archiv-European Journal of Physiology, 2017 - Springer
Tight junction (TJ) strands between epithelial or endothelial cells are formed by claudins, a
protein family comprising up to 27 members in mammals. Although many more proteins are …

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

MW van der Helm, OYF Henry, A Bein… - Lab on a Chip, 2019 - pubs.rsc.org
Here, we describe methods for combining impedance spectroscopy measurements with
electrical simulation to reveal transepithelial barrier function and tissue structure of human …

Epidermal tight junctions in health and disease

JM Brandner, M Zorn-Kruppa, T Yoshida, I Moll… - Tissue …, 2015 - Taylor & Francis
The skin, the largest organ of the body, is an essential barrier that under homeostatic
conditions efficiently protects and/or minimizes damage from both environmental (eg …

[HTML][HTML] Non-thermal effects of radiofrequency electromagnetic fields

P Wust, B Kortüm, U Strauss, J Nadobny… - Scientific Reports, 2020 - nature.com
We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and
established a theoretical framework to elucidate their electrophysiological mechanisms. In …

In vitro models of the blood–brain barrier

CJ Czupalla, S Liebner, K Devraj - Cerebral Angiogenesis: Methods and …, 2014 - Springer
The blood–brain barrier (BBB) proper is composed of endothelial cells (ECs) of the cerebral
microvasculature, which are interconnected by tight junctions (TJs) that in turn form a …

Microimpedance tomography system to monitor cell activity and membrane movements in a breathing lung-on-chip

Y Mermoud, M Felder, JD Stucki, AO Stucki… - Sensors and Actuators B …, 2018 - Elsevier
We report about a new microimpedance tomography (MITO) system integrated in a lung-on-
chip that recapitulates the thin alveolar barrier including the cyclic mechanical strain of the …

Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium

SS Zakrzewski, JF Richter, SM Krug, B Jebautzke… - PloS one, 2013 - journals.plos.org
Cell lines matching the source epithelium are indispensable for investigating porcine
intestinal transport and barrier properties on a subcellular or molecular level and …

Real-time cellular impedance monitoring and imaging of biological barriers in a dual-flow membrane bioreactor

L Cacopardo, J Costa, S Giusti… - Biosensors and …, 2019 - Elsevier
The generation of physiologically relevant in-vitro models of biological barriers can play a
key role in understanding human diseases and in the development of more predictive …

[HTML][HTML] Targeting the endocannabinoid system with microbial interventions to improve gut integrity

J Jansma, F Brinkman, S van Hemert… - Progress in Neuro …, 2021 - Elsevier
The endocannabinoid system is a metabolic pathway involved in the communication
between the gut microbiota and the host. In the gut, the endocannabinoid system regulates …