Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key
molecular features of Alzheimer's disease, production of amyloid-β peptides (extracellular …

Kinases remain an important drug target class within the pharmaceutical industry; however,
the rational design of kinase inhibitors is plagued by the complexity of gaining selectivity for …

To utilize the unique scaffold of a natural product indirubin, we herein adopted the strategy
of combined pharmacophores to design and synthesize a series of novel indirubin …

The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective
inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are …

Glycogen synthase kinase-3 (GSK-3) is a key enzyme involved in numerous physiological
events and in major diseases, such as Alzheimer's disease, diabetes, and cardiac …

To enhance the ability of indirubin derivatives to inhibit CDK2/cyclin E, a target of anticancer
agents, we designed and synthesized a new series of indirubin-3′-oxime derivatives with …

Members of the dual-specificity tyrosine-regulated kinase (DYRKs) subfamily possess a
distinctive capacity to phosphorylate tyrosine, serine, and threonine residues. Among the …

Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines,
exerting pharmacological potential in different aspects. They are known to play a crucial role …