Antimicrobial transformation products in the aquatic environment: global occurrence, ecotoxicological risks, and potential of antibiotic resistance

P Loffler, BI Escher, C Baduel, MP Virta… - … Science & Technology, 2023 - ACS Publications
The global spread of antimicrobial resistance (AMR) is concerning for the health of humans,
animals, and the environment in a One Health perspective. Assessments of AMR and …

The time and place for nature in drug discovery

RJ Young, SL Flitsch, M Grigalunas, PD Leeson… - Jacs Au, 2022 - ACS Publications
The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

Low levels of contaminants stimulate harmful algal organisms and enrich their toxins

E Agathokleous, J Peñuelas, RA Azevedo… - Environmental …, 2022 - ACS Publications
A widespread increase in intense phytoplankton blooms has been noted in lakes worldwide
since the 1980s, with the summertime peak intensity amplifying in most lakes. Such blooms …

Metformin contamination in global waters: Biotic and abiotic transformation, byproduct generation and toxicity, and evaluation as a pharmaceutical indicator

Y He, Y Zhang, F Ju - Environmental Science & Technology, 2022 - ACS Publications
Metformin is the first-line antidiabetic drug and one of the most prescribed medications
worldwide. Because of its ubiquitous occurrence in global waters and demonstrated …

Enrofloxacin induces intestinal microbiota-mediated immunosuppression in zebrafish

W Qiu, T Liu, X Liu, H Chen, S Luo… - … science & technology, 2022 - ACS Publications
The immunosuppressive effects of antibiotics and the potential associations with the
intestinal microbiota of the host have been increasingly recognized in recent years …

Distinct efficacies of interlayers in tailoring polyamide nanofiltration membrane performance for organic micropollutant removal: dependent on substrate characteristics

P Cheng, Y Liu, X Wei, K Fan, S **a - Environmental Science & …, 2024 - ACS Publications
Interlayered thin-film nanocomposite (TFN) membranes have shown the potential to boost
nanofiltration performance for water treatment applications including the removal of organic …

Exploring outputs of the intergovernmental science-policy panel on chemicals, waste, and pollution prevention

ML Diamond, G Sigmund, MG Bertram… - … & Technology Letters, 2024 - ACS Publications
The Science-Policy Panel (SPP) on Chemicals, Waste, and Pollution Prevention, now being
established under a mandate of the United Nations Environment Assembly, will address …

Biological-activity-based prioritization of antidepressants in wastewater in England and Japan

H Zhang, D Kato, MO Ihara, MD Jürgens… - Environmental …, 2023 - ACS Publications
Antidepressants are one of the most commonly prescribed pharmaceuticals. Although they
have been frequently detected in aquatic environments around the globe, little is known …

Human apparent volume of distribution predicts bioaccumulation of ionizable organic chemicals in zebrafish embryos

L Zhang, BW Brooks, F Liu, Z Zhou, H Li… - … Science & Technology, 2022 - ACS Publications
Chemicals with elevated bioaccumulation profiles present potential hazards to public health
and the environment. Ionizable organic compounds (IOCs) increasingly represent a large …

Transcriptome-Guided Characterization of the Environmental Toxicity of Metformin: Disruption of Energy Homeostasis and Inhibition of Embryonic Development of …

Z Zhang, H Shi, K Zhang, R An, C Wang… - Environmental …, 2024 - ACS Publications
Metformin has been widely detected in aquatic ecosystems, yet the knowledge of its impact
on aquatic organisms, particularly at environmentally relevant concentrations, remains …