Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

Heart disease is a major cause of death worldwide with increasing prevalence, which urges
the development of new therapeutic strategies. Over the last few decades, numerous small …

The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for develo** cardiovascular disease because of the …

Heart failure is a pressing public health problem with no curative treatment currently
available. The existing therapies provide symptomatic relief, but are unable to reverse …

Oxidative phosphorylation is an indispensable resource of ATP in tissues with high
requirement of energy. If the ATP demand is not met, studies suggest that this will lead to …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

The heart is responsible for pum** blood throughout the blood vessels to the periphery by
repeated, rhythmic contractions at variable intensity. As such the heart should permanently …

Metabolic adaption is crucial for the heart to sustain its contractile activity under various
physiological and pathological conditions. At the molecular level, the changes in energy …

Abstract Background Hydrogen sulfide (H 2 S) is an important regulator of mitochondrial
bioenergetics, but its role in regulating mitochondrial biogenesis is not well understood …