Beta-thalassemia is an inherited hemoglobinopathy characterized by the impaired synthesis
of beta-globin chains of hemoglobin leading to chronic hemolytic anemia. The mainstay of …

Thalassemia is a disease of erythrocytes that varies largely on its genetic composition and
associated clinical presentation. Though some patients may remain asymptomatic, those …

Purpose Erythroferrone (ERFE) is well acknowledged for its inhibitory function on hepcidin
synthesis in the liver during stress erythropoiesis, thereby ensuring sufficient iron supply to …

Thalassemia is one of the most important genetic haemolytic diseases that cause the
breakdown of red blood cells (RBCs) in patients with β-Thalassemia major. The body does …

Introduction: Thalassemia is a healthcare challenging disease all over the world. It imparts a
great burden on patients' families and healthcare institutions. Scientists focus on new …

BACKGROUND: Iron overload certainly will develop in β-thalassemia major. Iron
homeostasis was mostly regulated by hepcidin that synthesized in the liver and encoded by …

Abstract Background Aims: Hepcidin is low in β-thalassemia patients, suggesting a critical
role in iron accumulation. Hepcidin has not been assessed in Jordanian thalassemia …

OBJECTIVE: The objective was to determine the effect of ERFE hormone on hepcidin level
as iron metabolism regulator in patients with iron deficiency (ID). METHODS: The study …

Objectives: To investigate the significance of erythroferrone and hepcidin in β-thalassemia
patients in prediction of frequency of transfusions, iron overload, and its impact on …

Materials and Methods In this cross-sectional study, one hundred thalassemia patients were
recruited. Patient clinical and laboratory data including serum ferritin, liver and heart iron …