Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …
numerous biomedical applications. Bismuth-based compounds are used extensively as …
Targeted alpha-particle therapy: a review of current trials
Radiopharmaceuticals are rapidly develo** as a field, with the successful use of targeted
beta emitters in neuroendocrine tumors and prostate cancer serving as catalysts. Targeted …
beta emitters in neuroendocrine tumors and prostate cancer serving as catalysts. Targeted …
Revisiting the radiobiology of targeted alpha therapy
Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight
after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate …
after the approval of 223RaCl2 for patients with metastatic castration-resistant prostate …
A novel radiotherapeutic approach to treat bulky metastases even from cutaneous squamous cell carcinoma: its rationale and a look at the reliability of the linear …
G Ferini, P Castorina, V Valenti, SI Illari… - Frontiers in …, 2022 - frontiersin.org
Introduction Metastatic cutaneous squamous cell carcinoma (cSCC) is a very rare condition.
The lack of definition of an oligometastatic subgroup means that there is no consensus for its …
The lack of definition of an oligometastatic subgroup means that there is no consensus for its …
Immune checkpoint inhibition in non-melanoma skin Cancer: a review of current evidence
CJ Stonesifer, AR Djavid, JM Grimes, AE Khaleel… - Frontiers in …, 2021 - frontiersin.org
Immuno-oncology is a rapidly evolving field with growing relevance in the treatment of
numerous malignancies. The prior study of immunotherapy in dermatologic oncology has …
numerous malignancies. The prior study of immunotherapy in dermatologic oncology has …
Alpha dose modeling in diffusing alpha‐emitters radiation therapy—Part I: single‐seed calculations in one and two dimensions
Abstract Background Diffusing alpha‐emitters Radiation Therapy (“DaRT”) is a new method,
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
Antigen targeting and anti-tumor activity of a novel anti-CD146 212Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma
K Lindland, MM Malenge, RG Li, R Wouters… - Scientific Reports, 2024 - nature.com
Malignant mesothelioma, a highly aggressive cancer that primarily affects the serosal
membranes, has limited therapeutic options, particularly for cavitary tumors, such as …
membranes, has limited therapeutic options, particularly for cavitary tumors, such as …
The potentiation of anti-tumor immunity by tumor abolition with alpha particles, protons, or carbon ion radiation and its enforcement by combination with …
Y Keisari, I Kelson - Cells, 2021 - mdpi.com
The delivery of radiation therapy (RT) for cancer with intent to cure has been optimized and
standardized over the last 80 years. Both preclinical and clinical work emphasized the …
standardized over the last 80 years. Both preclinical and clinical work emphasized the …
Oncoimmunology meets organs-on-chip
Oncoimmunology represents a biomedical research discipline coined to study the roles of
immune system in cancer progression with the aim of discovering novel strategies to arm it …
immune system in cancer progression with the aim of discovering novel strategies to arm it …
RIG-1-like receptor activation synergizes with intratumoral alpha radiation to induce pancreatic tumor rejection, triple-negative breast metastases clearance, and …
V Domankevich, M Efrati, M Schmidt, E Glikson… - Frontiers in …, 2020 - frontiersin.org
Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated
seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside …
seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside …