Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

G Thomalla, F Boutitie, H Ma, M Koga, P Ringleb… - The Lancet, 2020‏ - thelancet.com
Background Patients who have had a stroke with unknown time of onset have been
previously excluded from thrombolysis. We aimed to establish whether intravenous …

Acute stroke management: overview and recent updates

M Hollist, L Morgan, R Cabatbat, K Au… - Aging and …, 2021‏ - pmc.ncbi.nlm.nih.gov
Stroke is a leading cause of morbidity and mortality in the United States. Whether
hemorrhagic or ischemic, stroke leads to severe long-term disability. Prior to the mid-1990s …

Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update

L Liu, Z Li, H Zhou, W Duan, X Huo, W Xu… - Stroke and vascular …, 2023‏ - svn.bmj.com
Background China is one of the countries with the highest burden of stroke. Implementing
multidimensional management guidelines will help clinicians practise evidence-based care …

Advances in acute ischemic stroke treatment: Current status and future directions

G Bathla, P Ajmera, PM Mehta, JC Benson… - American Journal of …, 2023‏ - ajnr.org
The management of acute ischemic stroke has undergone a paradigm shift in the past
decade. This has been spearheaded by the emergence of endovascular thrombectomy …

Thrombolysis with alteplase at 0.6 mg/kg for stroke with unknown time of onset: a randomized controlled trial

M Koga, H Yamamoto, M Inoue, K Asakura, J Aoki… - Stroke, 2020‏ - ahajournals.org
Background and Purpose—We assessed whether lower-dose alteplase at 0.6 mg/kg is
efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with …

CT for treatment selection in acute ischemic stroke: a code stroke primer

CA Potter, AS Vagal, M Goyal, DB Nunez… - Radiographics, 2019‏ - pubs.rsna.org
CT is the primary imaging modality used for selecting appropriate treatment in patients with
acute stroke. Awareness of the typical findings, pearls, and pitfalls of CT image interpretation …

Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges

T Leng, ZG **ong - Brain circulation, 2019‏ - journals.lww.com
Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive
efforts in search of brain injury mechanisms and therapeutic interventions, pharmacological …

A machine learning approach for classifying ischemic stroke onset time from imaging

KC Ho, W Speier, H Zhang, F Scalzo… - IEEE transactions on …, 2019‏ - ieeexplore.ieee.org
Current clinical practice relies on clinical history to determine the time since stroke (TSS)
onset. Imaging-based determination of acute stroke onset time could provide critical …

Is functional outcome different in posterior and anterior circulation stroke?

P Sommer, A Posekany, W Serles, M Marko, S Scharer… - Stroke, 2018‏ - ahajournals.org
Background and Purpose—Posterior circulation stroke (PCS) account for 20% of all
ischemic strokes. There is limited evidence whether functional outcome of PCS is …

[HTML][HTML] An automatic machine learning approach for ischemic stroke onset time identification based on DWI and FLAIR imaging

H Zhu, L Jiang, H Zhang, L Luo, Y Chen, Y Chen - NeuroImage: Clinical, 2021‏ - Elsevier
Current thrombolysis for acute ischemic stroke (AIS) treatment strictly relies on the time since
stroke (TSS) less than 4.5 h. However, some patients are excluded from thrombolytic …