Regulatory T cells (Tregs) are a small yet critical subset of CD4+ T cells, which have the role
of maintaining immune homeostasis by, for example, regulating self-tolerance, tumor …

Background Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous
autoimmune disease. A variety of immunological defects contribute to SLE, including …

The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in
recent decades: treatment decisions remain challenging in clinical practice, without a …

Guidelines and recommendations developed and/or endorsed by the American College of
Rheumatology (ACR) are intended to provide guidance for particular patterns of practice …

Caroline Gordon1, 2, 3, Maame-Boatemaa Amissah-Arthur1, Mary Gayed1, 3, Sue Brown4,
Ian N. Bruce5, 6, David D'Cruz7, Benjamin Empson8, Bridget Griffiths9, David Jayne10, 11 …

Objective: Systemic lupus erythematosus (SLE) is a complex disease with variable
presentations, course and prognosis. We sought to develop evidence-based …

Highlights•Solid organ transplantation (SOT) patients or patients with active ADs have been
largely excluded from ICIs clinical trials because of the risk of allograft rejection or severe …

Objective. To study the efficacy and safety of B cell depletion with rituximab, a chimeric
murine/human anti-CD20 monoclonal antibody, in patients with primary Sjögren's syndrome …

Context A variety of topical and systemic drugs are available to treat primary Sjögren
syndrome, although no evidence-based therapeutic guidelines are currently available …

Methods. Fifteen patients with primary SS were included in this phase II trial. Inclusion
criteria for the early primary SS group were B cell hyperactivity (IgG> 15 gm/liter), presence …