Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the
central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) shows …

Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age,
as well as after recurrent demyelination. Using RNA-sequencing to compare the gene …

To systematically characterize the loss of tissue integrity and organ dysfunction resulting
from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male …

Characterizing somatic mutations in the brain is important for disentangling the complex
mechanisms of aging, yet little is known about mutational patterns in different brain cell …

Old age is associated with a decline in cognitive function and an increase in
neurodegenerative disease risk. Brain ageing is complex and is accompanied by many …

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …

With the flourishing of spatial omics technologies, alignment and stitching of slices becomes
indispensable to decipher a holistic view of 3D molecular profile. However, existing …