The use of albendazole and mebendazole, ie, benzimidazole broad-spectrum anthelmintics,
in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are …

Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Cimetidine, the first H 2 receptor antagonist in widespread clinical use, has anti-cancer
properties that have been elucidated in a broad range of pre-clinical and clinical studies for …

Background: Although some benzimidazole-based anthelmintic drugs are found to possess
anticancer activity, their modes of binding interactions have not been reported. Methodology …

Existing computational methods for drug repositioning either rely only on the gene
expression response of cell lines after treatment, or on drug-to-disease relationships …

Anticancer treatment efficacy is limited by the development of refractory tumor cells
characterized by increased expression and activity of mechanisms promoting survival …

Although potential anticancer activities of benzimidazole-based anthelmintic drugs have
been approved by preclinical and clinical studies, modes of binding interactions have not …

The development of refractory tumor cells limits therapeutic efficacy in cancer by activating
mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …