Therapeutic plasticity of neural stem cells
L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
Systematic reconstruction of cellular trajectories across mouse embryogenesis
Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …
Neural stem cell niche and adult neurogenesis
Y Li, W Guo - The Neuroscientist, 2021 - journals.sagepub.com
Adult neurogenesis is a process that generates new and functional neurons from neural
stem cells (NSCs) in a specialized neurogenic niche throughout life. Misregulated …
stem cells (NSCs) in a specialized neurogenic niche throughout life. Misregulated …
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation
W Jiang, F Zhu, H Xu, L Xu, H Li, X Yang… - Science …, 2023 - science.org
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain
and is known as a reliable biomarker for inflammatory central nervous system (CNS) …
and is known as a reliable biomarker for inflammatory central nervous system (CNS) …
Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition
B Zhang, L Wang, A Zhan, M Wang, L Tian… - Nature …, 2021 - nature.com
Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a
variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the …
variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the …
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling
Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an
important function in diverse biological processes and diseases. However, the roles of Ogt in …
important function in diverse biological processes and diseases. However, the roles of Ogt in …
The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors
Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but
otherwise maintains unknown disease origins. Unfortunately, little progress has been made …
otherwise maintains unknown disease origins. Unfortunately, little progress has been made …
Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
H Li, L Xu, W Jiang, X Qiu, H Xu, F Zhu, Y Hu, S Liang… - Cell Reports, 2023 - cell.com
Cognitive impairment has been associated with an age-related decline in adult hippocampal
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …
[HTML][HTML] Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging
Within the adult central nervous system (CNS) of most mammals resides a resident stem cell
population, known as neural stem cells (NSCs). NSCs are located within specific niches of …
population, known as neural stem cells (NSCs). NSCs are located within specific niches of …
Communication, cross talk, and signal integration in the adult hippocampal neurogenic niche
C Vicidomini, N Guo, A Sahay - Neuron, 2020 - cell.com
Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …