Macrophage plasticity and polarization: in vivo veritas
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …
Macrophage plasticity and polarization in tissue repair and remodelling
Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
PS Liu, H Wang, X Li, T Chao, T Teav, S Christen… - Nature …, 2017 - nature.com
Glutamine metabolism provides synergistic support for macrophage activation and elicitation
of desirable immune responses; however, the underlying mechanisms regulated by …
of desirable immune responses; however, the underlying mechanisms regulated by …
The role of macrophage phenotype in vascularization of tissue engineering scaffolds
Angiogenesis is crucial for the success of most tissue engineering strategies. The natural
inflammatory response is a major regulator of vascularization, through the activity of different …
inflammatory response is a major regulator of vascularization, through the activity of different …
Macrophage-derived glutamine boosts satellite cells and muscle regeneration
Muscle regeneration is sustained by infiltrating macrophages and the consequent activation
of satellite cells,,–. Macrophages and satellite cells communicate in different ways,,,–, but …
of satellite cells,,–. Macrophages and satellite cells communicate in different ways,,,–, but …
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
Recruitment of tumor-associated macrophages (TAMs) into avascular areas sustains tumor
progression; however, the underlying guidance mechanisms are unknown. Here, we report …
progression; however, the underlying guidance mechanisms are unknown. Here, we report …
Orchestration of metabolism by macrophages
Metabolic adaptation is a key component of macrophage plasticity and polarization,
instrumental to their function in homeostasis, immunity, and inflammation. Macrophage …
instrumental to their function in homeostasis, immunity, and inflammation. Macrophage …
Pharmacologic targeting of hypoxia-inducible factors
GL Semenza - Annual review of pharmacology and toxicology, 2019 - annualreviews.org
Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …
MET is required for the recruitment of anti-tumoural neutrophils
Mutations or amplification of the MET proto-oncogene are involved in the pathogenesis of
several tumours,,,, which rely on the constitutive engagement of this pathway for their growth …
several tumours,,,, which rely on the constitutive engagement of this pathway for their growth …
[HTML][HTML] Pharmacologic or genetic targeting of glutamine synthetase skews macrophages toward an M1-like phenotype and inhibits tumor metastasis
Summary Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate,
controls important events, including the release of inflammatory mediators, mammalian …
controls important events, including the release of inflammatory mediators, mammalian …