CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

VD Bock, H Hiemstra… - European Journal of …, 2006 - Wiley Online Library
CuI‐catalyzed alkyne–azide cycloaddition provides 1, 4‐disubstituted 1, 2, 3‐triazoles with
such efficiency and scope that the transformation has been described as “click” chemistry …

A review on biological activities and chemical synthesis of hydrazide derivatives

R Narang, B Narasimhan… - Current medicinal …, 2012 - ingentaconnect.com
There has been considerable interest in the development of novel compounds with
anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory, antiplatelet …

Bioactive 1, 2, 3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications

L da SM Forezi, CGS Lima, AAP Amaral… - The Chemical …, 2021 - Wiley Online Library
The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …

Synthesis, HIV-RT inhibitory activity and SAR of 1-benzyl-1H-1, 2, 3-triazole derivatives of carbohydrates

FC da Silva, MCBV de Souza, IIP Frugulhetti… - European journal of …, 2009 - Elsevier
This paper describes the synthesis of several 1-benzyl-1H-1, 2, 3-triazoles attached to
different carbohydrate templates and their in vitro inhibitory profile against HIV-1 reverse …

Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N'-(5-bromo-2-hydroxybenzylidene) …

K Karrouchi, S Fettach, MM Jotani, A Sagaama… - Journal of Molecular …, 2020 - Elsevier
In this present work, the newly synthesized compound E)-N'-(5-bromo-2-
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …

Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung …

Y **a, CD Fan, BX Zhao, J Zhao, DS Shin… - European journal of …, 2008 - Elsevier
A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives
were synthesized and the effects of all the compounds on A549 cell growth were …

Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1, 2, 3-triazole derivatives

MS Costa, N Boechat, EA Rangel, FC Da Silva… - Bioorganic & medicinal …, 2006 - Elsevier
The aim of this work was to describe the synthesis, the in vitro anti-Mycobacterium
tuberculosis profile, and the structure–activity relationship (SAR) study of new N-substituted …

Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells

LW Zheng, LL Wu, BX Zhao, WL Dong… - Bioorganic & medicinal …, 2009 - Elsevier
A series of novel 3-aryl-1-(4-tert-butylbenzyl)-1H-pyrazole-5-carbohydrazide hydrazone
derivatives were synthesized and the effects of all the compounds on A549 cell growth were …

New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives

GA Silva, LMM Costa, FCF Brito, ALP Miranda… - Bioorganic & medicinal …, 2004 - Elsevier
In this work, we reported the synthesis and evaluation of the analgesic, antiinflammatory,
and antiplatelet properties of new phenothiazine-attached acylhydrazone derivatives (6) …

Immobilization of porphyrinatocopper nanoparticles onto activated multi‐walled carbon nanotubes and a study of its catalytic activity as an efficient heterogeneous …

H Sharghi, MH Beyzavi, A Safavi… - Advanced Synthesis …, 2009 - Wiley Online Library
An efficient, regioselective, one‐pot and two‐step synthesis of β‐hydroxy 1, 4‐disubstituted
1, 2, 3‐triazoles from a wide range of non‐activated terminal alkynes and epoxides and …