As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Sex-based disparities in immune responses are well known phenomena. The two most
important factors accounting for the sex-bias in immunity are genetics and sex hormones …

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune
responses according to peripheral cues. After four decades of research, we now know that …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

Chemokines have crucial roles in organ development and orchestration of leukocyte
migration. The chemokine CCL22 is expressed constitutively at high levels in the lymph …

Recently, it has become clear that short-chain fatty acids (SCFAs), and in particular butyrate,
have anti-inflammatory properties. Murine studies have shown that butyrate can promote …

Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological
role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining …

Preclinical studies show that locoregional CTLA-4 blockade is equally effective in inducing
tumor eradication as systemic delivery, without the added risk of immune-related side …