PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid organ transplantation
K Geneugelijk, E Spierings - Immunogenetics, 2020 - Springer
Human leukocyte antigen (HLA) mismatches between donors and recipients may lead to
alloreactivity after solid organ transplantation. Over the last few decades, our knowledge of …
alloreactivity after solid organ transplantation. Over the last few decades, our knowledge of …
Human leukocyte antigen molecular mismatch to risk stratify kidney transplant recipients
C Wiebe, PW Nickerson - Current Opinion in Organ …, 2020 - journals.lww.com
All alloimmunity is driven by differences between donors and recipients at the molecular
level. HLA molecular mismatch may represent a fast, reproducible, cost-effective, way to …
level. HLA molecular mismatch may represent a fast, reproducible, cost-effective, way to …
Analysis of T and B Cell Epitopes to Predict the Risk of de novo Donor-Specific Antibody (DSA) Production After Kidney Transplantation: A Two-Center Retrospective …
S Sakamoto, K Iwasaki, T Tomosugi… - Frontiers in …, 2020 - frontiersin.org
Risk prediction of de novo donor specific antibody (DSA) would be very important for long
term graft outcome after organ transplantation. The purpose of this study was to elucidate the …
term graft outcome after organ transplantation. The purpose of this study was to elucidate the …
[HTML][HTML] On path to informing hierarchy of eplet mismatches as determinants of kidney transplant loss
Introduction To mitigate risks related to human leukocyte antigen (HLA) incompatibility, we
assessed whether certain structurally defined HLA targets present in donors but absent from …
assessed whether certain structurally defined HLA targets present in donors but absent from …
[HTML][HTML] The quest to decipher HLA immunogenicity: telling friend from foe
AR Tambur, H McDowell, R Hod-Dvorai… - American journal of …, 2019 - Elsevier
Molecular mismatch load analysis was recently introduced as a means for performing risk
stratification following organ transplantation. However, although good correlation was …
stratification following organ transplantation. However, although good correlation was …
Comparison of human leukocyte antigen immunologic risk stratification methods in lung transplantation
SJ Hiho, BJ Levvey, MB Diviney, GI Snell… - American Journal of …, 2024 - Elsevier
Outcomes after lung transplantation (LTx) remain poor, despite advances in sequencing
technology and development of algorithms defining immunologic compatibility. Presently …
technology and development of algorithms defining immunologic compatibility. Presently …
Predictive value of molecular matching tools for the development of donor specific HLA‐antibodies in patients undergoing lung transplantation
L Kleid, J Walter, M Vorstandlechner, CP Schneider… - HLA, 2023 - Wiley Online Library
Molecular matching is a new approach for virtual histocompatibility testing in organ
transplantation. The aim of our study was to analyze whether the risk for de novo donor …
transplantation. The aim of our study was to analyze whether the risk for de novo donor …
[HTML][HTML] Specific human leucocyte antigen-DQ risk epitope mismatches are associated with chronic lung allograft dysfunction after lung transplantation
SL Ennis, N Olsen, WWY Tong, L Goddard… - American Journal of …, 2023 - Elsevier
A high-risk epitope mismatch (REM)(found in DQA1∗ 05+ DQB1∗ 02/DQB1∗ 03: 01) is
associated with de novo donor specific antibodies after lung transplantation (LTx). Chronic …
associated with de novo donor specific antibodies after lung transplantation (LTx). Chronic …
Determining clinical thresholds for donor HLA eplet compatibility to predict best outcomes following lung transplantation
Background. Currently, the assessment of immunological risk in lung transplantation (LTx)
does not completely consider HLA compatibility at the molecular level. We have previously …
does not completely consider HLA compatibility at the molecular level. We have previously …
Postoperative outcomes of lung transplant recipients with preformed donor-specific antibodies
OBJECTIVES Few studies have evaluated the outcomes of lung transplantation (LTx) in
recipients with preformed donor-specific antibodies (DSAs). This study investigated the …
recipients with preformed donor-specific antibodies (DSAs). This study investigated the …