Recent gene expression profiling of breast cancer has identified specific subtypes with
clinical, biologic, and therapeutic implications. The basal-like group of tumors is …

Breast cancer is highly prevalent in females and accounts for second highest number of
deaths, worldwide. Cumbersome, expensive and time consuming detection techniques …

Germline mutations of the BRCA1 gene account for approximately 5% of breast and ovarian
cancer cases, and lower than normal BRCA1 expression or function may be an important …

The BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast
cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of …

Learning Objectives After completing this course, the reader will be able to: List the
biomarkers that are currently used and those that may be of potential use in the …

BRCA1 is a tumor suppressor gene which, when mutated, is associated with the
development of hereditary breast cancers. In sporadic tumors, although inherent gene …

Breast cancer is the second leading cause of cancer deaths and is the most frequently
diagnosed cancer in women of industrialized nations. Breast cancer progression is a …

BRCA1 germline mutations predispose women to early onset, familial breast and
ovariancancer. BRCA1 has been recently implicated in the cellular response to agents that …

Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast
tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the …

In this study we describe a novel interaction between the breast/ovarian tumor suppressor
gene BRCA1 and the transcription factor GATA3, an interaction, which is important for …