The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

Simple Summary A new class of drugs, termed Immune Checkpoint Inhibitors, has
revolutionized cancer therapy during the last few years. Unfortunately, these drugs are only …

Four inflammatory diseases are strongly associated with Major Histocompatibility Complex
class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A* 29: 02), ankylosing …

The 'MHC-I (major histocompatibility complex class I)-opathy'concept describes a family of
inflammatory conditions with overlap** clinical manifestations and a strong genetic link to …

Purpose: This study sought to evaluate the expression of programmed cell death-ligand-1
(PD-L1) and HLA class I on neuroblastoma cells and programmed cell death-1 (PD-1) and …

Behçet's disease (BD) is a complex, recurring inflammatory disorder with autoinflammatory
and autoimmune components. This comprehensive review aims to explore BD's …

Despite the significant clinical advances with the use of immune checkpoint inhibitors (ICIs)
in a wide range of cancer patients, response rates to the therapy are variable and do not …

The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …

The association between carriage of the human leucocyte antigen (HLA)-B* 51 allele and
development of Behçet's disease (BD) has been known since the early 1970s, but the exact …