Biogenesis and function of transfer RNA-related fragments (tRFs)

P Kumar, C Kuscu, A Dutta - Trends in biochemical sciences, 2016 - cell.com
Noncoding small RNAs arise from the various un-annotated and annotated regions of the
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …

Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases

Y Shen, X Yu, L Zhu, T Li, Z Yan, J Guo - Journal of Molecular Medicine, 2018 - Springer
The number of studies on non-coding RNAs has increased substantially in recent years
owing to their importance in gene regulation. However, the biological functions of small …

IsomiRs–the overlooked repertoire in the dynamic microRNAome

CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants

JS Yang, EC Lai - Molecular cell, 2011 - cell.com
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes

P Pawlica, TA Yario, S White, J Wang, WN Moss… - Proceedings of the …, 2021 - pnas.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease (COVID-19), continues to be a pressing health concern. In this study …

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

N Cloonan, S Wani, Q Xu, J Gu, K Lea, S Heater… - Genome biology, 2011 - Springer
Abstract Background Variants of microRNAs (miRNAs), called isomiRs, are commonly
reported in deep-sequencing studies; however, the functional significance of these variants …

Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection

Q Wang, I Lee, J Ren, SS Ajay, YS Lee, X Bao - Molecular therapy, 2013 - cell.com
The discovery of small noncoding RNAs (sncRNAs) with regulatory functions is a recent
breakthrough in biology. Among sncRNAs, microRNA (miRNA), derived from host or virus …

[HTML][HTML] Beyond microRNA–novel RNAs derived from small non-coding RNA and their implication in cancer

ES Martens-Uzunova, M Olvedy, G Jenster - Cancer letters, 2013 - Elsevier
Over the recent years, Next Generation Sequencing (NGS) technologies targeting the
microRNA transcriptome revealed the existence of many different RNA fragments derived …

Viral noncoding RNAs: more surprises

KT Tycowski, YE Guo, N Lee, WN Moss… - Genes & …, 2015 - genesdev.cshlp.org
Eukaryotic cells produce several classes of long and small noncoding RNA (ncRNA). Many
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …

Structure of transfer RNAs: similarity and variability

R Giegé, F Jühling, J Pütz, P Stadler… - Wiley …, 2012 - Wiley Online Library
Transfer RNAs (tRNAs) are ancient molecules whose origin goes back to the beginning of
life on Earth. Key partners in the ribosome‐translation machinery, tRNAs read genetic …