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Biogenesis and function of transfer RNA-related fragments (tRFs)
Noncoding small RNAs arise from the various un-annotated and annotated regions of the
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …
genome. When they arise from annotated genes, the noncoding small RNAs are functionally …
Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases
Y Shen, X Yu, L Zhu, T Li, Z Yan, J Guo - Journal of Molecular Medicine, 2018 - Springer
The number of studies on non-coding RNAs has increased substantially in recent years
owing to their importance in gene regulation. However, the biological functions of small …
owing to their importance in gene regulation. However, the biological functions of small …
IsomiRs–the overlooked repertoire in the dynamic microRNAome
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …
SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease (COVID-19), continues to be a pressing health concern. In this study …
coronavirus disease (COVID-19), continues to be a pressing health concern. In this study …
MicroRNAs and their isomiRs function cooperatively to target common biological pathways
N Cloonan, S Wani, Q Xu, J Gu, K Lea, S Heater… - Genome biology, 2011 - Springer
Abstract Background Variants of microRNAs (miRNAs), called isomiRs, are commonly
reported in deep-sequencing studies; however, the functional significance of these variants …
reported in deep-sequencing studies; however, the functional significance of these variants …
Identification and functional characterization of tRNA-derived RNA fragments (tRFs) in respiratory syncytial virus infection
The discovery of small noncoding RNAs (sncRNAs) with regulatory functions is a recent
breakthrough in biology. Among sncRNAs, microRNA (miRNA), derived from host or virus …
breakthrough in biology. Among sncRNAs, microRNA (miRNA), derived from host or virus …
[HTML][HTML] Beyond microRNA–novel RNAs derived from small non-coding RNA and their implication in cancer
Over the recent years, Next Generation Sequencing (NGS) technologies targeting the
microRNA transcriptome revealed the existence of many different RNA fragments derived …
microRNA transcriptome revealed the existence of many different RNA fragments derived …
Viral noncoding RNAs: more surprises
Eukaryotic cells produce several classes of long and small noncoding RNA (ncRNA). Many
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …
Structure of transfer RNAs: similarity and variability
Transfer RNAs (tRNAs) are ancient molecules whose origin goes back to the beginning of
life on Earth. Key partners in the ribosome‐translation machinery, tRNAs read genetic …
life on Earth. Key partners in the ribosome‐translation machinery, tRNAs read genetic …