Synthetic cells revisited: Artificial cell construction using polymeric building blocks

V Maffeis, L Heuberger, A Nikoletić… - Advanced …, 2024 - Wiley Online Library
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …

Polymersomes for therapeutic protein and peptide delivery: towards better loading properties

C Hua, L Qiu - International Journal of Nanomedicine, 2024 - Taylor & Francis
Therapeutics based on proteins and peptides have profoundly transformed the landscape of
treatment for diseases, from diabetes mellitus to cancers, yet the short half-life and low …

Protocells Capable of Generating a Cytoskeleton‐Like Structure from Intracellular Membrane‐Active Artificial Organelles

D Wang, S Moreno, M Gao, J Guo, B Xu… - Advanced functional …, 2023 - Wiley Online Library
The intricate nature of eukaryotic cells with intracellular compartments having differences in
component concentration and viscosity in their lumen provides (membrane‐active) enzymes …

Protein–polymer bioconjugation, immobilization, and encapsulation: a comparative review towards applicability, functionality, activity, and stability

B Çalbaş, AN Keobounnam, C Korban… - Biomaterials …, 2024 - pubs.rsc.org
Polymer-based biomaterials have received a lot of attention due to their biomedical,
agricultural, and industrial potential. Soluble protein–polymer bioconjugates, immobilized …

Stretched or wrinkled? Looking into the polymer conformation within polymersome membranes

C Effenberg, J Gaitzsch - Soft Matter, 2024 - pubs.rsc.org
Self-assembly of amphiphilic block-copolymers into polymersomes is a well-established
concept. In this membrane, the hydrophilic part is considered to be loosely assembled …

Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems-In Honor of Wolfgang Meier

CG Palivan, L Heuberger, J Gaitzsch, B Voit… - …, 2024 - ACS Publications
The fundamental building block of living organisms is the cell, which is the universal
biological base of all living entities. This micrometric mass of cytoplasm and the membrane …

Multimodal Imaging, Drug Delivery, and On‐Board Triggered Degradation in Soft Capsule Rolling Microrobots

D Castellanos‐Robles, RCLM Doineau… - Advanced Intelligent …, 2024 - Wiley Online Library
In the rapidly advancing field of medical microrobotics, designing robots capable of
addressing various challenges—such as imaging, biodegradation, and multifunctionality—is …

Facile approach to fabricate stable multi-chamber colloid particles for compartmentalized encapsulation and reaction control of incompatible molecules

H Chen, M Hu, X Tan, X Han, J Gao, L Ma… - Chemical Engineering …, 2023 - Elsevier
Compartmentalized delivery systems can achieve simultaneous encapsulation of multiple
guest cargos in independent spaces and are becoming a topic of tremendous interest in …

Reversible crowdedness of pH-responsive and host–guest active polymersomes: Mimicking µm-sized cell structures

K Zhang, Y Zhou, S Moreno, S Schwarz, S Boye… - Journal of Colloid and …, 2024 - Elsevier
The structure–function characteristics of isolated artificial organelles (AOs) in protocells are
mainly known, but there are few reports on clustered or aggregated AOs. To imitate µm …

Stable and permeable polyion complex vesicles designed as enzymatic nanoreactors

Y Wan, Y Qiu, J Zhou, J Liu, MAC Stuart, Y Peng… - Soft Matter, 2024 - pubs.rsc.org
Polymeric vesicles are perspective vehicles for fabricating enzymatic nanoreactors towards
diverse biomedical and catalytic applications, yet the design of stable and permeable …