Due to the growing number of young patients at risk of germ cell loss, there is a need to
preserve spermatogonial stem cells for patients who are not able to bank spermatozoa …

In the not so distant past, pregnancy for women with transfusion-dependent thalassemia
(TDT) was considered very high risk and often not recommended. As management of these …

Sustained donor engraftment after allogeneic hematopoietic cell transplantation (HCT)
converts to healthy donor hemoglobin synthesis and halts disease symptoms in patients with …

Women with β-thalassemia (BT) and sickle cell disease (SCD) have a high risk of infertility
and premature ovarian insufficiency. Different fertility preserving strategies, including …

Zinc fluctuations regulate key steps in late oocyte and preimplantation embryo development;
however, roles for zinc in preceding stages in early ovarian follicle development, when …

Abstract In 1963 George Mathé announced to the world that he had cured a patient of
leukaemia by means of a bone-marrow transplant. Since than much progress has been …

Hemochromatosis (HC) is characterized by the progressive accumulation of iron in the body,
resulting in organ damage. Endocrine complications are particularly common, especially …

Abstract β-thalassaemia major (BTM) has a high prevalence worldwide and is associated
with considerable morbidity and mortality. The aim of this review is to provide an illustrative …

Allogeneic hematopoietic stem cell transplantation (HSCT) can cure transfusion-dependent
thalassemia (TDT). In a multicenter trial we investigated the efficacy of reduced-intensity …

Survival of individuals with transfusion-dependent thalassemia (TDT) has significantly
increased during the years due to improvement in multidisciplinary comprehensive care …