PSMA-targeting imaging and theranostic agents—Current status and future perspective

S Debnath, N Zhou, M McLaughlin, S Rice… - International journal of …, 2022‏ - mdpi.com
In the past two decades, extensive efforts have been made to develop agents targeting
prostate-specific membrane antigen (PSMA) for prostate cancer imaging and therapy. To …

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and …

Z Kazemi, N Moini, HA Rudbari… - Medicinal Research …, 2024‏ - Wiley Online Library
Chirality is a fundamental and widespread geometric structural property in living organisms
that most biomacromolecules including nucleic acids, proteins and enzymes, possess …

Unprecedented Inversion of Selectivity and Extraordinary Difference in the Complexation of Trivalent f Elements by Diastereomers of a Methylated Diglycolamide

A Wilden, PM Kowalski, L Klaß, B Kraus… - … A European Journal, 2019‏ - Wiley Online Library
When considering f elements, solvent extraction is primarily used for the removal of
lanthanides from ore and their recycling, as well as for the separation of actinides from used …

Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu (II) complexes of vitamin B6 derivative

B Annaraj, MA Neelakantan - European Journal of Medicinal Chemistry, 2015‏ - Elsevier
The synthesis and characterization of Copper (II) complexes of a Schiff base derived from
vitamin B6 component (pyridoxal) and ethanol amine [CuL 2](1), and its mixed ligand …

Synthesis and Evaluation of 68Ga- and 177Lu-Labeled (R)- vs (S)-DOTAGA Prostate-Specific Membrane Antigen-Targeting Derivatives

R Zhao, K Ploessl, Z Zha, S Choi, D Alexoff… - Molecular …, 2020‏ - ACS Publications
Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer cells and
therefore is an attractive target for prostate cancer diagnosis and radionuclide therapy …

High in Vivo Stability of 64Cu-Labeled Cross-Bridged Chelators Is a Crucial Factor in Improved Tumor Imaging of RGD Peptide Conjugates

S Sarkar, N Bhatt, YS Ha, PT Huynh… - Journal of Medicinal …, 2018‏ - ACS Publications
Although the importance of bifunctional chelators (BFCs) is well recognized, the
chemophysical parameters of chelators that govern the biological behavior of the …

Bifunctional bispidine derivatives for copper-64 labelling and positron emission tomography

A Roux, R Gillet, S Huclier-Markai… - Organic & …, 2017‏ - pubs.rsc.org
The first radiolabelling studies of a bispidine (3, 7-diazabicyclo [3.3. 1] nonane) derivative
substituted by a glycinate pendant arm (L1) with 64Cu are reported. Labelling was fast and …

Efficient Synthesis of the Pyoverdine Chromophore: Expanding the Toolbox for the Preparation of Pyoverdine Conjugates

T Zhang, A Bolhuis, IM Eggleston - European Journal of …, 2024‏ - Wiley Online Library
The pyoverdine chromophore is an important component of a family of siderophores which
are secreted by the human pathogen Pseudomonas aeruginosa for iron absorption. In this …

Synthesis of a Bifunctional Cross‐Bridged Chelating Agent, Peptide Conjugation, and Comparison of 68Ga Labeling and Complex Stability Characteristics with …

H Damerow, B Wängler, R Schirrmacher… - …, 2023‏ - Wiley Online Library
Abstract [68Ga] Ga3+ can be introduced into receptor‐specific peptidic carriers via different
chelators to obtain radiotracers for Positron Emission Tomography imaging and the chosen …

Matching chelators to radiometals for positron emission tomography imaging-guided targeted drug delivery

H Deng, H Wang, Z Li - Current Drug Targets, 2015‏ - benthamdirect.com
Positron emission tomography (PET) is a functional imaging modality that measures
pathophysiology status of disease noninvasively, and has become a key component for …