Cell movements are essential for animal development and homeostasis but also contribute
to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to …

Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with
diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally …

Gamete development is a fundamental process that is highly conserved from early
eukaryotes to mammals. As germ cells develop, they must coordinate a dynamic series of …

Focal adhesion (FA) turnover depends on microtubules and actin. Microtubule ends are
captured at FAs, where they induce rapid FA disassembly. However, actin's roles are less …

Background The actin bundling protein Fascin is essential for developmental cell migrations
and promotes cancer metastasis. In addition to bundling actin, Fascin has several actin …

Transposons are known to participate in tissue aging, but their effects on aged stem cells
remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) …

While prostaglandins (PGs), short-range lipid signals, regulate single cell migration, their
roles in collective migration remain unclear. To address this, we use Drosophila border cell …

Understanding how different cell types acquire their motile behaviour is central to many
normal and pathological processes. Drosophila border cells represent a powerful model for …

Adenomatous polyposis coli (APC) is a large multidomain protein that regulates the
cytoskeleton. Recently, it was shown that vertebrate APC through its Basic domain directly …

Adenomatous polyposis coli (APC) is widely recognized as a heavily mutated gene that
suppresses tumor growth in colorectal cancer (CRC). Its mutation is considered to be the …