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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
[HTML][HTML] Rethinking next-generation vaccines for coronaviruses, influenzaviruses, and other respiratory viruses
Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …
XBB. 1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN. 1
COVID-19 vaccines have recently been updated to specifically encode or contain the spike
protein of the SARS-CoV-2 XBB. 1.5 subvariant, but their immunogenicity in humans has yet …
protein of the SARS-CoV-2 XBB. 1.5 subvariant, but their immunogenicity in humans has yet …
Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
distinct spike mutations resulting in escape from antibodies induced by previous infection or …
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …
concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity
Rapid recognition of SARS-CoV-2–infected cells by resident T cells in the upper airway
might provide an important layer of protection against COVID-19. Whether parenteral SARS …
might provide an important layer of protection against COVID-19. Whether parenteral SARS …