Circuit coordination of opposing neuropeptide and neurotransmitter signals

ME Soden, JX Yee, LS Zweifel - Nature, 2023 - nature.com
Fast-acting neurotransmitters and slow, modulatory neuropeptides are co-released from
neurons in the central nervous system, albeit from distinct synaptic vesicles. The …

Neurotensin and alcohol use disorders: Towards a pharmacological treatment

FD Rodríguez, ML Sánchez, R Coveñas - International Journal of …, 2023 - mdpi.com
Harmful alcohol use is responsible for a group of disorders collectively named alcohol use
disorders (AUDs), according to the DSM-5 classification. The damage induced by alcohol …

SIRT1 in the BNST modulates chronic stress-induced anxiety of male mice via FKBP5 and corticotropin-releasing factor signaling

P Hu, Y Wang, XH Qi, QH Shan, ZH Huang… - Molecular …, 2023 - nature.com
Although clinical reports have highlighted association of the deacetylase sirtuin 1 (SIRT1)
gene with anxiety, its exact role in the pathogenesis of anxiety disorders remains unclear …

Differential CRH expression level determines efficiency of Cre-and Flp-dependent recombination

C Zhao, C Ries, Y Du, J Zhang, K Sakimura… - Frontiers in …, 2023 - frontiersin.org
Corticotropin-releasing hormone expressing (CRH+) neurons are distributed throughout the
brain and play a crucial role in sha** the stress responses. Mouse models expressing site …

Distinct dynamics and intrinsic properties in ventral tegmental area populations mediate reward association and motivation

JE Elum, ER Szelenyi, B Juarez, AD Murry, G Loginov… - Cell reports, 2024 - cell.com
Ventral tegmental area (VTA) dopamine neurons regulate reward-related associative
learning and reward-driven motivated behaviors, but how these processes are coordinated …

Corticotropin releasing factor (CRF) coexpression in GABAergic, glutamatergic, and GABA/glutamatergic subpopulations in the central extended amygdala and ventral …

JL Fudge, EA Kelly, TA Hackett - Journal of Neuroscience, 2022 - Soc Neuroscience
The central extended amygdala (CEA) and ventral pallidum (VP) are involved in diverse
motivated behaviors based on rodent models. These structures are conserved, but …

Whole‐brain connectivity to the bed nucleus of the stria terminalis calretinin‐expressing interneurons in male mice

KW Zhu, GJ Tao, ZL Huang, WM Qu… - European Journal of …, 2023 - Wiley Online Library
The bed nucleus of the stria terminalis (BNST) is a neuropeptide‐enriched brain region that
modulates a wide variety of emotional behaviours and states, including stress, anxiety …

Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption

AA Worth, CH Feetham, NA Morrissey… - Frontiers in …, 2024 - frontiersin.org
Background The part played by oxytocin and oxytocin neurons in the regulation of food
intake is controversial. There is much pharmacological data to support a role for oxytocin …

CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

PT Huijgens, R Heijkoop, LJMJ Vanderschuren… - …, 2024 - Springer
This study aims to investigate the underlying neurobiological mechanisms that regulate
natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose …

Whole‐brain map** of monosynaptic afferent inputs to the CRH neurons in the medial prefrontal cortex of mice

XL Li, F Li, XY Zhu, XD Wang, ZZ Kou… - Journal of …, 2024 - Wiley Online Library
Corticotropin‐releasing hormone (CRH) neurons are densely distributed in the medial
prefrontal cortex (mPFC), which plays a crucial role in integrating and processing emotional …