Biomarker-based staging of Alzheimer disease: rationale and clinical applications

J Therriault, SE Schindler, G Salvadó… - Nature Reviews …, 2024 - nature.com
Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …

Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia

LM Winchester, EL Harshfield, L Shi… - Alzheimer's & …, 2023 - Wiley Online Library
With the increase in large multimodal cohorts and high‐throughput technologies, the
potential for discovering novel biomarkers is no longer limited by data set size. Artificial …

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

M Milà-Alomà, NJ Ashton, M Shekari, G Salvadó… - Nature medicine, 2022 - nature.com
Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's
disease are needed to facilitate the initial screening process of participants in disease …

Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer's disease model mice

Y Chen, Y Li, Y Fan, S Chen, L Chen, Y Chen… - Gut …, 2024 - Taylor & Francis
The gut microbiota (GM) and its metabolites affect the host nervous system and are involved
in the pathogeneses of various neurological diseases. However, the specific GM alterations …

Alzheimer's disease: exploring the landscape of cognitive decline

R Tenchov, JM Sasso, QA Zhou - ACS Chemical Neuroscience, 2024 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is …

[HTML][HTML] Diagnostic biomarkers of amyloid and tau pathology in Alzheimer's disease: an overview of tests for clinical practice in the United States and Europe

L Iaccarino, SC Burnham, G Dell'Agnello… - The Journal of …, 2023 - Elsevier
Amyloid and tau biomarkers for Alzheimer's disease are widely recognized diagnostic tools
for the identification of Alzheimer's disease pathology antemortem and are recommended by …

The future of (radio)‐labeled compounds in research and development within the life science industry

V Derdau, CS Elmore, T Hartung… - Angewandte Chemie …, 2023 - Wiley Online Library
In this review the applications of isotopically labeled compounds are discussed and put into
the context of their future impact in the life sciences. Especially discussing their use in the …

Association of glial fibrillary acid protein, Alzheimer's disease pathology and cognitive decline

DE Peretti, C Boccalini, F Ribaldi, M Scheffler… - Brain, 2024 - academic.oup.com
Increasing evidence shows that neuroinflammation is a possible modulator of tau spread
effects on cognitive impairment in Alzheimer's disease. In this context, plasma levels of the …

Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods

A Jovalekic, N Roé-Vellvé, N Koglin… - European Journal of …, 2023 - Springer
Purpose Amyloid positron emission tomography (PET) with [18F] florbetaben (FBB) is an
established tool for detecting Aβ deposition in the brain in vivo based on visual assessment …

[PDF][PDF] Amyloid-β and phosphorylated tau are the key biomarkers and predictors of Alzheimer's disease

H Reddy, S Kshirsagar, MA Islam, J Baig… - Aging and …, 2025 - researchgate.net
Alzheimer's disease (AD) is a age-related neurodegenerative disease and is a major public
health concern both in Texas, US and Worldwide. This neurodegenerative disease is mainly …