Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Cancer is a global issue majorly affecting develo** countries. According to a survey, 63%
of deaths due to cancer are reported from develo** countries. There are different …

Findings over the past decade have identified aberrant activation of the ETS transcription
factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

Low grade serous ovarian tumours are a rare and under-characterised histological subtype
of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of …

The ERG gene is fused to TMPRSS2 in approximately 50% of prostate cancers (PrCa),
resulting in its overexpression. However, whether this is the sole mechanism underlying …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …