Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

A deep understanding of how the brain controls behaviour requires map** neural circuits
down to the muscles that they control. Here, we apply automated tools to segment neurons …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

Since the Cambrian, animals diversified from a few body forms or bauplans, into many
extinct and all extant species. A characteristic neural architecture serves each bauplan. How …

Mammalian cortex features a vast diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity powerfully shapes …

A primary cilium is a membrane-bound extension from the cell surface that contains
receptors for perceiving and transmitting signals that modulate cell state and activity. Primary …

Like the vertebrate spinal cord, the insect ventral nerve cord (VNC) mediates limb sensation
and motor control. Here, we applied automated tools for electron microscopy (EM) volume …

Advances in Electron Microscopy, image segmentation and computational infrastructure
have given rise to large-scale and richly annotated connectomic datasets which are …