Polygenic risk scores: from research tools to clinical instruments

CM Lewis, E Vassos - Genome medicine, 2020 - Springer
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …

Clinical utility of polygenic risk scores for coronary artery disease

D Klarin, P Natarajan - Nature Reviews Cardiology, 2022 - nature.com
Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Genetic determinism, essentialism and reductionism: semantic clarity for contested science

KP Harden - Nature Reviews Genetics, 2023 - nature.com
Research linking genetic differences with human social and behavioural phenotypes has
long been controversial. Frequently, debates about the ethical, social and legal implications …

New literacy challenge for the twenty-first century: genetic knowledge is poor even among well educated

R Chapman, M Likhanov, F Selita, I Zakharov… - Journal of community …, 2019 - Springer
We live in an age of rapidly advancing genetic research. This research is generating new
knowledge that has implications for personal health and well-being. The present study …

Teaching for genetics literacy in the post-genomic era

F Stern, K Kampourakis - Studies in Science Education, 2017 - Taylor & Francis
Research in genetics and genomics is advancing at a fast pace, and thus kee** up with
the most recent findings and conclusions can be very challenging. At the same time these …

Defining epigenetic literacy: How to integrate epigenetics into the biology curriculum

N Gericke, B Mc Ewen - Journal of Research in Science …, 2023 - Wiley Online Library
The aim of this study is to define epigenetic literacy and describe how it can be included in
school biology. Epigenetics is a new field of research in biology with abundant societal …

Exploring relationships among belief in genetic determinism, genetics knowledge, and social factors

N Gericke, R Carver, J Castéra, NAM Evangelista… - Science & …, 2017 - Springer
Genetic determinism can be described as the attribution of the formation of traits to genes,
where genes are ascribed more causal power than what scientific consensus suggests …

Potential use of clinical polygenic risk scores in psychiatry–ethical implications and communicating high polygenic risk

AC Palk, S Dalvie, J De Vries, AR Martin… - Philosophy, Ethics, and …, 2019 - Springer
Psychiatric disorders present distinct clinical challenges which are partly attributable to their
multifactorial aetiology and the absence of laboratory tests that can be used to confirm …

Police officers, stigma, and the opioid epidemic

NE Kruis, J Choi, RH Donohue - International Journal of …, 2020 - journals.sagepub.com
Researchers have suggested that provider-based stigma of substance use disorders is one
barrier to fighting the opioid epidemic. Yet, to date, virtually no study has examined provider …

Free will, determinism, and intuitive judgments about the heritability of behavior

EA Willoughby, AC Love, M McGue, WG Iacono… - Behavior genetics, 2019 - Springer
The fact that genes and environment contribute differentially to variation in human
behaviors, traits and attitudes is central to the field of behavior genetics. Perceptions about …